Note: it is not a peptide, but a small molecule that blocks the enzyme NNMT. It has only been studied in cells and mice as a possible obesity treatment.
Regulatory status
Not approved
Family
NNMT enzyme inhibitor (small molecule, not a peptide)
No safety data in humans. Sold as a "research compound" without quality control. Its use only makes sense in research or under medical supervision; buying it is not recommended.
Effect by goal · level of evidence
Diet-induced obesity in mice
reducesLowpreclinical (A)animals / laboratory
In mice made obese by a high-fat diet, the inhibitor reduced weight, fat mass, adipocyte size, and total cholesterol in 11 days, without changing what they ate.
Inhibits nicotinamide N-methyltransferase (NNMT), an enzyme that is highly active in the fat of people with obesity. Blocking it raises NAD+ and SAM in adipocytes and slows fat formation.
What the evidence says
In people
There are no published trials in people.
In animals or the laboratory
Diet-induced obesity in mice. In mice made obese by a high-fat diet, the inhibitor reduced weight, fat mass, adipocyte size, and total cholesterol in 11 days, without changing what they ate. PubMed 29155147