Lengthened version of Argireline used in cosmetics against expression wrinkles. It has only been studied in people within multi-ingredient products, so it is impossible to know how much of the effect is its own.
FDA (US): Not approved as a drug (sold as a cosmetic ingredient)
EMA (EU): Not authorized as a drug (cosmetic ingredient in the EU)
Dose
There is no established dose in humans.
Safety
In topical cosmetics it is usually well tolerated; it may cause local irritation or redness. There are no long-term safety data or data in pregnancy. Do a patch test on a small area before using it.
Effect by goal · level of evidence
Eye-contour wrinkles (microneedle patch)
reducesLowclinical trial (A)in people
−25.8% fine lines
12-week trial with no placebo group using hyaluronic acid microneedle patches that combined acetyl octapeptide-3 with other peptides, adenosine, and algae: fine lines fell by 25.8% and hydration rose by 15.4%. Several authors work at companies in the industry.
24 people used a microneedle patch with acetyl octapeptide-3 (plus vitamin C and other actives) overnight on one eye and a hyaluronic acid placebo on the other for 28 days; wrinkles and elasticity improved more on the treated side, with no adverse effects. Study by the manufacturing company.
Like Argireline, it mimics a fragment of SNAP-25 to interfere with acetylcholine release and, in theory, relax the muscle contraction that creates wrinkles. Its actual passage through the skin is not well demonstrated.
What the evidence says
In people
Eye-contour wrinkles (microneedle patch). 12-week trial without a placebo group using hyaluronic acid microneedle patches that combined acetyl octapeptide-3 with other peptides, adenosine, and algae: fine lines fell by 25.8% and hydration rose by 15.4%. Several authors work for companies in the industry. PubMed 31134751
Periocular wrinkles vs placebo. 24 people wore a microneedle patch with acetyl octapeptide-3 (plus vitamin C and other actives) overnight on one eye and a hyaluronic acid placebo on the other for 28 days; wrinkles and elasticity improved more on the treated side, with no adverse effects. Study by the manufacturing company. PubMed 39082657