It depends on the case; there is no single guideline.
Cohort of 559 women ≥65 years: high serum levels of an AGE (CML) predicted higher cardiovascular mortality (HR ~1.94) after adjusting for age and BMI. Observational: association, cause not proven.
View the study (study) →AGEs (advanced glycation end products) are compounds that form when sugars react non-enzymatically with proteins or fats—a process called glycation—. Carboxymethyl-lysine (CML) is the most studied AGE and is measured in blood as a biomarker.
They are generated in two ways: endogenously, favored by high, sustained glucose levels (hence their relevance in diabetes), and exogenously, in foods cooked at high temperature and with dry heat (frying, roasting, toasting, grilling), whereas boiling or steaming generates far fewer.
Once in the body, AGEs accumulate in tissues and activate the RAGE receptor, triggering inflammation and oxidative stress. Elevated levels are associated with complications of diabetes, cardiovascular and kidney disease, and with tissue aging; for that reason they are studied as a risk marker and as a target that can be modified through diet and glycemic control.
Information, not medical advice. Prescription drugs require a doctor.
Information, not medical advice. Scientific evidence reflects the quality of the studies.