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Prescription drug

Atomoxetine

A non-stimulant for ADHD (Strattera): a selective norepinephrine reuptake inhibitor. An option when stimulants are not wanted or not tolerated.
Category
Prescription drug
Scientific evidence
High
Number of findings
1
Sources
Our own summaries · Cited studies
Dosage and how to use
By prescription; the effect sets in over weeks (not immediate). Dose by weight/response, adjusted by the physician.

In practice

By prescription; the effect sets in over weeks (not immediate). Dose by weight/response, adjusted by the physician.

Precautions

Prescription drug with follow-up. Effects: digestive discomfort, drowsiness, increased blood pressure/heart rate; warning to monitor for suicidal ideation in young people and for rare hepatotoxicity.

Effect by goal · level of evidence

ADHD

improves Very high network meta-analysis (AAA)

As a non-stimulant, atomoxetine is effective on ADHD symptoms although generally somewhat less so than stimulants in direct comparison (Cortese 2018); useful when avoiding stimulants is preferred.

View the source (network meta-analysis) →

In depth

Atomoxetine

⏱ 3 min read

A non-stimulant for ADHD (Strattera): a selective norepinephrine reuptake inhibitor. An option when stimulants are not wanted or not tolerated.

How it works

It selectively inhibits the norepinephrine transporter, increasing norepinephrine (and, indirectly, dopamine) in the prefrontal cortex, without the classic stimulant profile.

Efficacy and use

Its effect is gradual (weeks). It is a first- or second-line option when nonstimulants are preferred, when there is a risk of abuse, or when anxiety/tics coexist. It has no potential for misuse.

Safety

Monitoring of blood pressure, heart rate and mood; watch for suicidal ideation at the start of treatment in minors. Indication and adjustment are medical.

References

  1. Cortese, S. et al. (2018). Comparative efficacy and tolerability of medications for ADHD in children, adolescents, and adults: a systematic review and network meta-analysis. Lancet Psychiatry 5(9), 727-738. PMID:30097390

Information, not medical advice. Prescription drug: its indication, dose, and monitoring are up to a health professional.

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