Food

Barley and rye (hordein, secalin)

Dietary factor.

In practice

It depends on the case; there is no single guideline.

Effect by goal · level of evidence

Celiac disease

harms Low-moderate study (A)

In duodenal biopsies from people with celiac disease, the prolamins of barley (hordein) and rye (secalin) triggered inflammation (IFN-γ) just like wheat gliadin. It supports excluding barley and rye on a gluten-free diet. Ex vivo study, small sample.

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In depth

Diet · Highest evidence: Low-moderate · 1 finding

Findings

Celiac disease — harms (Low-moderate, study). In duodenal biopsies from people with celiac disease, barley prolamins (hordein) and rye prolamins (secalin) triggered inflammation (IFN-γ) just like wheat gliadin. Supports excluding barley and rye from the gluten-free diet. Ex vivo study, small sample. 16629935

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Information, not medical advice. Scientific evidence reflects the quality of the studies.