Supplement

Bifidobacterium longum 1714

A psychobiotic strain developed by PrecisionBiotics. Unlike JB-1, it has shown positive signals in healthy humans: it attenuates cortisol reactivity to acute stress and improves perceived daily stress and sleep quality.

How to take it

1×10^9 CFU/day for 4–8 weeks. Commercial product: Zenflore®.

Safety

Very well tolerated; trials reported no relevant adverse events. Caution in severe immunosuppression.

Effect by goal · level of evidence

Acute stress in healthy humans

improves (modest) Moderate RCT (n=22) (A)

↓ Reactive cortisol

4 weeks of 1×10^9 CFU/day in 22 healthy people: attenuates the rise in cortisol and subjective anxiety during the 'socially evaluated cold pressor test'. Reduction in reported daily stress. One of the few psychobiotics with a positive human signal.

View the study (RCT (n=22)) →

Sleep and well-being

improves (modest) Moderate RCT (AA)

Modest improvement

Double-blind RCT 2024: 6 weeks of the strain improves subjective sleep quality and well-being indices in healthy adults vs placebo.

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Acute social stress (EEG)

improves Low-moderate pilot RCT (A)

Electrophysiological effect

The strain modulates brain activity (EEG) during acute social stress, consistent with an anxiolytic effect. Small samples.

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Gut-brain axis

association Moderate human evidence (AA)

Positive human translation

Example with the best human translation among psychobiotics. Useful profile in stressed healthy populations; effect in clinical disorders awaits trials.

View the study (RCT) →

Information, not medical advice. Scientific evidence reflects the quality of the studies.