It depends on the case; there is no single guideline.
Safety review: the four classes of caramel color have passed extensive toxicological testing and are considered safe at usual exposures; attention focuses on by-products such as 4-MeI. It is a review (regulatory/industry sector).
View the study (study) →Diet · Highest evidence: Low · 1 finding
Information, not medical advice. Prescription drugs require a doctor.
Information, not medical advice. Scientific evidence reflects the quality of the studies.