Food

Coffee / caffeine (by CYP1A2 genotype)

Dietary factor.

In practice

It depends on the case; there is no single guideline.

Effect by goal · level of evidence

Risk of myocardial infarction

association Moderate study (A)

Case-control (2,014 cases): in slow caffeine metabolizers (CYP1A2*1F variant), more coffee was associated with a higher risk of heart attack; in fast metabolizers it was not. An association that depends on genetics (case-control).

View the study (study) →

In depth

Diet · Highest evidence: Moderate · 1 finding

Findings

Myocardial infarction risk — association (Moderate, study). Case-control (2,014 cases): in slow caffeine metabolizers (CYP1A2*1F variant), more coffee was associated with a higher risk of heart attack; in fast metabolizers it was not. An association that depends on genetics (case-control). 16522833

Information, not medical advice. Prescription drugs require a doctor.

Information, not medical advice. Scientific evidence reflects the quality of the studies.