It depends on the case; there is no single guideline.
Composition study: the polyphenol content (antioxidants such as chlorogenic acid) and caffeine content of coffee depend on the variety and, above all, the roast; lighter roasts tend to retain more polyphenols. The roast changes how much antioxidant it provides.
View the study (study) →Diet · Highest evidence: Low · 1 finding
Information, not medical advice. Prescription drugs require a doctor.
Information, not medical advice. Scientific evidence reflects the quality of the studies.