It depends on the case; there is no single guideline.
Effect by goal · level of evidence
Child neurodevelopment (IQ)
harmsLow-moderatemeta-analysis (AAA)
Meta-analysis: HIGH fluoride exposure (especially areas with heavily fluoridated water) was associated with somewhat lower IQ in children. Studies mostly observational and of high exposures; it is unclear that it applies to usual water fluoridation. Controversial topic.
Child neurodevelopment (IQ) — harms (Low-moderate, meta-analysis). Meta-analysis: HIGH fluoride exposure (especially areas with heavily fluoridated water) was associated with somewhat lower IQ in children. Studies mostly observational and of high exposures; it is unclear that it applies to usual water fluoridation. Controversial topic. 22820538
Information, not medical advice. Prescription drugs require a doctor.
Information, not medical advice. Scientific evidence reflects the quality of the studies.