Supplement

Glucosamine and chondroitin

Supplement.

How to take it

There is no established standard dose for this case; it is advisable to consult a professional.

Effect by goal · level of evidence

Knee osteoarthritis (pain)

no clear effect High study (AA)

Large trial (GAIT, 1,583 patients, 24 weeks) versus placebo and celecoxib: neither glucosamine, nor chondroitin, nor their combination clearly outperformed placebo overall. In the subgroup with moderate-to-severe pain, the combination showed a possible improvement (exploratory analysis).

View the study (study) →

In depth

Supplement · Highest evidence: High · 1 finding

Findings

Knee osteoarthritis (pain) — no clear effect (High, study). Large trial (GAIT, 1,583 patients, 24 weeks) versus placebo and celecoxib: neither glucosamine, nor chondroitin, nor their combination clearly outperformed placebo overall. In the subgroup with moderate-to-severe pain, the combination showed a possible improvement (exploratory analysis). 16495392

Information, not medical advice. Prescription drugs require a doctor.

Information, not medical advice. Scientific evidence reflects the quality of the studies.