Prescription drug

Icosapent ethyl (pure EPA)

Prescription drug.

How to take it

There is no established standard dose for this case; it is advisable to consult a professional.

Safety

High-dose prescription drug.

Effect by goal · level of evidence

Cardiovascular events with high triglycerides

reduces Very high study (A)

25%

REDUCE-IT trial: in patients on a statin with high triglycerides, icosapent ethyl (pure EPA, 4 g/day) reduced cardiovascular events by ~25%. Unlike mixed fish oil (EPA+DHA), high-dose pure EPA did show benefit (although the mineral oil placebo was debated).

View the study (study) →

In depth

Drug · Highest evidence: Very high · 1 finding

⚠️ Prescription drug at a high dose.

Findings

Cardiovascular events with high triglycerides — reduces (Very high, study). REDUCE-IT trial: in patients on a statin with high triglycerides, icosapent ethyl (pure EPA, 4 g/day) reduced cardiovascular events by ~25%. Unlike mixed fish oil (EPA+DHA), high-dose pure EPA did show benefit (although the mineral oil placebo was debated). 30415628

Information, not medical advice. Prescription drugs require a doctor.

Information, not medical advice. Scientific evidence reflects the quality of the studies.