High leptin = satiety; high ghrelin = hunger. In obesity, despite high leptin, there is leptin resistance in the hypothalamus: people eat without perceiving satiety.
View the study (review) →A chronic inflammatory state and excess adiposity cause leptin resistance. Reducing inflammation (omega-3, exercise, sleep) restores sensitivity.
View the study (review) →Lack of sleep raises ghrelin and lowers leptin: you eat more the next day. Sleeping 7-9 h is one of the most effective interventions for regulating appetite.
View the study (RCT) →Intermittent fasting reduces baseline ghrelin in the medium term after adaptation (2-4 weeks). It explains why, a few weeks after starting, you are 'no longer hungry at noon'.
View the study (RCT) →Information, not medical advice. Scientific evidence reflects the quality of the studies.