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Prescription drug

Lisdexamfetamine

A prodrug of dexamfetamine (Elvanse/Vyvanse) for ADHD; increases the release of dopamine and norepinephrine. Long-acting stimulant.
Category
Prescription drug
Scientific evidence
Very high
Number of findings
1
Sources
Our own summaries · Cited studies
Dosage and how to use
By prescription; one daily dose thanks to its gradual release as it is converted into dexamfetamine. Dose individualized by the physician.

In practice

By prescription; one daily dose thanks to its gradual release as it is converted into dexamfetamine. Dose individualized by the physician.

Precautions

Prescription drug with follow-up. Effects: reduced appetite, insomnia, dry mouth, increased blood pressure/heart rate; potential for misuse (amphetamine). Cardiovascular and psychiatric caution.

Effect by goal · level of evidence

ADHD

improves Very high network meta-analysis (AAA)

Amphetamine stimulants are among those with the greatest efficacy on ADHD symptoms in the comparative evidence (Cortese 2018), especially valued in adults; lisdexamfetamine offers a steady release throughout the day.

View the source (network meta-analysis) →

In depth

Lisdexamfetamine

⏱ 3 min read

A prodrug of dexamfetamine (Elvanse/Vyvanse) for ADHD; increases the release of dopamine and norepinephrine. Long-acting stimulant.

How it works

As a prodrug, it is converted in the body into dextroamphetamine, which increases the release and reduces the reuptake of dopamine and norepinephrine, improving sustained attention.

Efficacy and use

Very effective on the core symptoms; the prodrug formulation aims for a prolonged action and a lower relative potential for abuse. It is used when a long-acting stimulant is preferred.

Safety

Same cardiovascular and sleep/appetite precautions as other stimulants, with control because of its potential for misuse. Indication and adjustment are always a medical matter.

References

  1. Cortese, S. et al. (2018). Comparative efficacy and tolerability of medications for ADHD in children, adolescents, and adults: a systematic review and network meta-analysis. Lancet Psychiatry 5(9), 727-738. PMID:30097390

Information, not medical advice. Prescription drug: its indication, dose, and monitoring are up to a health professional.

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