It depends on the case; there is no single guideline.
Effect by goal · level of evidence
Cholesterol and LDL particle size
associationLow-moderatestudy (AA)
In 105 healthy men, a low-fat, high-carbohydrate diet led some to shift from large, 'fluffy' LDL (pattern A) to small, dense LDL (pattern B), considered more atherogenic. Nuance: lowering fat does not work the same for everyone.
Cholesterol and LDL particle size — association (Low-moderate, study). In 105 healthy men, a low-fat, high-carbohydrate diet made some shift from large, 'fluffy' LDL (pattern A) to small, dense LDL (pattern B), considered more atherogenic. Nuance: lowering fat does not suit everyone equally. 7625363
Information, not medical advice. Prescription drugs require a doctor.
Information, not medical advice. Scientific evidence reflects the quality of the studies.