It depends on the case; there is no single guideline.
Effect by goal · level of evidence
Cardiovascular risk, cancer and reproduction
harmsLowstudy (A)
Review: nicotine itself (separate from smoke) has effects on the cardiovascular system and reproduction, but the major cancer risk of tobacco comes mainly from combustion, not from nicotine. It is not harmless, although without smoke the risk profile changes.
Cardiovascular risk, cancer, and reproduction — harms (Low, study). Review: nicotine itself (separate from smoke) has effects on the cardiovascular system and on reproduction, but the major cancer risk of tobacco comes mainly from combustion, not from nicotine. It is not harmless, although without smoke the risk profile changes. 32595938
Information, not medical advice. Prescription drugs require a doctor.
Information, not medical advice. Scientific evidence reflects the quality of the studies.