Climbing plant (Passiflora incarnata) with flavonoids that modulate GABA-A. A mild anxiolytic used mainly for situational anxiety, initial insomnia, and as a substitute for benzodiazepines for procedures.
250–800 mg/day of standardized extract. At night for insomnia; 30–60 min before the dreaded situation for anticipatory anxiety. An infusion is also available (2 g of dried leaf).
How to take it
250–800 mg/day of standardized extract. At night for insomnia; 30–60 min before the dreaded situation for anticipatory anxiety. An infusion is also available (2 g of dried leaf).
Safety
Very well tolerated. Mild drowsiness at high doses. Caution with sedatives, MAOIs, and anticoagulants. Avoid in pregnancy.
Effect by goal · level of evidence
Situational / preoperative anxiety
improvesModerateRCT (AA)
Like midazolam without the hangover
500 mg of Passiflora 90 min before dental or outpatient surgery: anxiety reduction comparable to oral midazolam without residual sedation or amnesia.