It depends on the case; there is no single guideline.
Effect by goal · level of evidence
Muscle protein synthesis after training
improvesModeratestudy (AA)
In 24 trained men, spreading 80 g of whey protein after exercise as 4 doses of 20 g every 3 h stimulated muscle protein synthesis more than a few large doses or many small ones. Supports spreading protein in moderate doses; it measures a marker, not long-term muscle mass.
Muscle protein synthesis after training — improves (Moderate, study). In 24 trained men, spreading 80 g of whey protein after exercise as 4 doses of 20 g every 3 h stimulated more muscle protein synthesis than a few large doses or many small ones. Supports spreading protein across moderate doses; it measures a marker, not long-term muscle mass. 23459753
Information, not medical advice. Prescription drugs require a doctor.
Information, not medical advice. Scientific evidence reflects the quality of the studies.