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Prescription drug

Rapamycin (sirolimus)

Prescription drug.
Scientific evidence
Low
Number of findings
1
Sources
Our own summaries · Cited studies

How to take it

There is no established standard dose for this case; it is advisable to consult a professional.

Safety

Immunosuppressant; human use only under a physician or in a trial

Effect by goal · level of evidence

Longevity / cardiac function (canine, preliminary)

improves (preclinical/veterinary) Low trial (RCT in dogs) (A)

At low doses, rapamycin improved markers of cardiac function (ejection fraction, E/A ratio) in healthy middle-aged dogs, with no clinical adverse effects over 10 weeks. A geroprotection signal that fuels interest in longevity, but it is in DOGS and a prescription immunosuppressant: not extrapolable to healthy people.

View the study (trial (RCT in dogs)) →

In depth

Drug · Highest evidence: Low · 1 finding

⚠️ immunosuppressant; human use only under a physician or in a trial

Findings

  • Longevity / cardiac function (canine, preliminary) — improves (preclinical/veterinary) (Low, trial (RCT in dogs)). At low doses, rapamycin improved markers of cardiac function (ejection fraction, E/A ratio) in healthy middle-aged dogs, with no clinical adverse effects over 10 weeks. A geroprotection signal that fuels interest in longevity, but it is in DOGS and a prescription immunosuppressant: not extrapolable to healthy people. 28374166

Information, not medical advice. Prescription drugs require a doctor.

Information, not medical advice. Scientific evidence reflects the quality of the studies.

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