It depends on the case; there is no single guideline.
Analysis of the RISCK trial: carriers of the APOE4 gene lowered cholesterol and apoB more than E3/E3 when replacing saturated fat with low-glycemic-index carbohydrates. It suggests that the diet's effect on cholesterol depends in part on genetics.
View the study (study) →Information, not medical advice. Scientific evidence reflects the quality of the studies.