Peptide
Tripeptide-10 citrulline (Decorinyl)
Tetrapeptide that mimics a fragment of decorin, a protein that organizes collagen fibers. The efficacy claims come from the manufacturer: we have not found studies published in PubMed on this ingredient.
Regulatory status
Cosmetic and topical
Family
Signal peptide (decorin mimetic)
Where it acts
Skin and aging
Also known as
Decorinyl, tripeptide-10 citrulline, tripeptide-10 citrulline
Regulatory status
FDA (US): Not approved as a drug (sold as a cosmetic ingredient)
EMA (EU): Not authorized as a drug (cosmetic ingredient in the EU)
Dose
There is no established dose in humans.
Safety
In topical cosmetics it is usually well tolerated; it may cause local irritation or redness. There are no long-term safety data or data in pregnancy. Do a patch test on a small area before using it.
In depth
Where it acts
Skin and aging
How it works
It was designed to mimic the region of decorin that binds to collagen and thus regulate the thickness and organization of fibers, which become disordered with age. There are no independent studies confirming this.
What the evidence says
In people
There are no published trials in people.
Information, not medical advice. Evidence for cosmetic ingredients tends to be small and funded by manufacturers.