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Mechanism

HPA axis (hypothalamic-pituitary-adrenal)

Connects with 21 factors and 3 health goals.

In depth

HPA axis (hypothalamic-pituitary-adrenal)

⏱ 2 min read

The HPA axis is the hormonal circuit that governs the stress response. In the face of a threat, the hypothalamus releases CRH, the pituitary responds with ACTH, and the adrenal glands secrete cortisol, which mobilizes energy and prepares the body. A feedback system then returns levels to normal.

The problem appears when the axis stays activated: chronically elevated cortisol affects sleep, mood, immunity, and metabolism. On this map it connects with cortisol and stress, psychoneurobiology, sleep, the vagus nerve, and goals such as anxiety, depression, or chronic stress. Sleeping well, breathing, exercise, and adapting to stressors act on this axis.

Educational information, not medical advice.

Factors that act through this pathway

Supplements

AshwagandhaL-theanineMagnesiumRhodiolaTaurineTongkat AliPhosphatidylserineSchisandraLactobacillus rhamnosus JB-1 (psychobiotic)Bifidobacterium longum 1714 (psychobiotic)Eleuthero (Siberian ginseng)

Nutrients

Pantothenic acid (Vitamin B5)

Lifestyle

Contact with natureCold exposure4-7-8 breathingAlternate nostril breathing (Nadi Shodhana)

Related pathways and factors

DopamineNorepinephrine (noradrenaline)OxytocinNeuropeptide Y (NPY)Cortisol

Related goals

AnxietyChronic stress and HPAGeneralized anxiety disorder (GAD)

Information, not medical advice.

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