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Bone health

Bone health is built throughout life: bone mass accumulates until "peak bone mass" at around age 25-30, is maintained for 1-2 decades, and begins to be lost from the fifth decade, with notable acceleration in women during the 5… Read more.

14 factors with evidence, ordered from highest to lowest effectiveness. Information, not medical advice.

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In depth

⏱ 3 min read

Bone health is built throughout life: bone mass accumulates until "peak bone mass" at around age 25-30, is maintained for 1-2 decades, and begins to be lost from the fifth decade, with a notable acceleration in women during the 5-10 years after menopause because of the drop in estrogen. Osteoporosis (very low bone mineral density with an increased risk of fragility fracture) is one of the main causes of morbidity, dependence, and mortality in older adults, especially hip fracture. Preventive interventions have an enormous margin.

What matters most: strength training

The most effective stimulus for maintaining and increasing bone density is not nutritional but mechanical: progressive strength training with significant loads. The LIFTMOR trial (2018) showed notable improvements in bone density in postmenopausal women with osteopenia/osteoporosis after 8 months of supervised high-intensity training (squats, deadlifts, presses), with an excellent safety profile.

Recommendation: 2-3 weekly strength sessions with multijoint exercises (squat, deadlift, press, row) at 60-85% of 1RM, with sustained progression; complemented with impact exercise (jumping, running) when it is safe, plus balance and mobility work. This intervention far surpasses walking as a bone stimulus.

Learning technique with professional guidance at the start is important for safety and progression.

Calcium and vitamin D: the nutritional foundation

Calcium: 1000-1200 mg/day in adults, preferably from whole foods (dairy, small fish eaten with the bones, leafy green vegetables, legumes, seeds, almonds). Supplements only in people with insufficient dietary intake or with established osteoporosis (with simultaneous vitamin D, avoiding very high doses).

Vitamin D: correct subclinical deficiencies with 1000-2000 IU/day; keeping 25-OH-D between 30-50 ng/mL is a reasonable goal. Essential for calcium absorption and mineralization.

Vitamin K2 (MK-7) (90-180 µg/day): activates osteocalcin; a key synergy with D3. Especially useful when high doses of D and calcium are used, to direct calcium to bone and not to vessels.

Magnesium (200-400 mg/day): cofactor in vitamin D activation and a bone component; subclinical deficiency is common.

Adequate protein (1.0-1.2 g/kg/day, up to 1.5 in older adults): the myth that "too much protein decalcifies" is incorrect; low protein intake is more problematic.

Vitamin K1 and other trace elements (boron, zinc, manganese, silicon, copper): minor cofactors with modest support, covered by a varied diet.

What damages bone

  • Sedentary lifestyle.
  • Tobacco: a clear risk factor for osteoporosis.
  • Excessive alcohol.
  • Chronic corticosteroids: glucocorticoid-induced osteoporosis.
  • Low body weight, severe calorie restriction, eating disorders.
  • Hormonal deficiencies (male hypogonadism, untreated early menopause, hypothalamic amenorrhea in athletes).
  • Some drugs: aromatase inhibitors, androgen deprivation, certain anticonvulsants, PPIs at high chronic doses, prolonged heparin.
  • Diseases: hyperthyroidism, hyperparathyroidism, malabsorption, IBD, celiac disease, CKD.

Bone densitometry (DEXA) and diagnosis

Bone mineral density is measured with DEXA. Indications: women ≥ 65 years, men ≥ 70, history of fragility fracture, family history, early menopause, significant risk factors. Results: - Normal: T-score > -1. - Osteopenia: T-score between -1 and -2.5. - Osteoporosis: T-score ≤ -2.5. - Severe osteoporosis: T-score ≤ -2.5 with a fragility fracture.

Drugs: when

In established osteoporosis or a fracture risk greater than 20% at 10 years (FRAX), oral or intravenous bisphosphonates are first-line treatment with robust data showing reduced vertebral, non-vertebral, and hip fractures (alendronate, risedronate, zoledronic acid). Alternatives: denosumab, teriparatide, romosozumab depending on context. Hormone replacement therapy in menopause also has a bone-preserving effect, although it is not mainly used for that indication.

When to see a doctor

Fragility fracture (with minimal trauma), significant height loss, persistent bone pain, and significant risk factors from age 50-60 are indications for evaluation with bone densitometry.

The reasonable conclusion

Long-term bone health is built on: regular progressive strength training from an early age as the main pillar, adequate calcium intake (preferably from food), sufficient vitamin D, K2 when appropriate, adequate protein, and avoiding tobacco and excessive alcohol. In established osteoporosis, pharmacological interventions are necessary and effective, complemented by structural measures. Fall prevention (balance training, medication review, adapting the environment) is key in older adults to prevent catastrophic fractures.

References

  1. Watson, S.L. et al. (2018). High-intensity resistance and impact training improves bone mineral density and physical function in postmenopausal women with osteopenia and osteoporosis: the LIFTMOR randomized controlled trial. J Bone Miner Res 33, 2. doi:10.1002/jbmr.3284
  2. Howe, T.E. et al. (2011). Exercise for preventing and treating osteoporosis in postmenopausal women. Cochrane Database Syst Rev 7. doi:10.1002/14651858.CD000333.pub2
  3. Knapen, M.H. et al. (2013). Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos Int 24, 9. doi:10.1007/s00198-013-2325-6
  4. Bauer, J. et al. (2013). Evidence-based recommendations for optimal dietary protein intake in older people. J Am Med Dir Assoc 14, 8. doi:10.1016/j.jamda.2013.05.021
  5. Camacho, P.M. et al. (2020). American Association of Clinical Endocrinologists/American College of Endocrinology Clinical Practice Guidelines for the Diagnosis and Treatment of Postmenopausal Osteoporosis. Endocr Pract 26, suppl 1. doi:10.4158/GL-2020-0524SUPPL
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Bone health

⏱ 3 min read

Bone health is built throughout life: bone mass accumulates until "peak bone mass" at around age 25-30, is maintained for 1-2 decades, and begins to be lost from the fifth decade, with a notable acceleration in women during the 5-10 years after menopause because of the drop in estrogen. Osteoporosis (very low bone mineral density with an increased risk of fragility fracture) is one of the main causes of morbidity, dependence, and mortality in older adults, especially hip fracture. Preventive interventions have an enormous margin.

What matters most: strength training

The most effective stimulus for maintaining and increasing bone density is not nutritional but mechanical: progressive strength training with significant loads. The LIFTMOR trial (2018) showed notable improvements in bone density in postmenopausal women with osteopenia/osteoporosis after 8 months of supervised high-intensity training (squats, deadlifts, presses), with an excellent safety profile.

Recommendation: 2-3 weekly strength sessions with multijoint exercises (squat, deadlift, press, row) at 60-85% of 1RM, with sustained progression; complemented with impact exercise (jumping, running) when it is safe, plus balance and mobility work. This intervention far surpasses walking as a bone stimulus.

Learning technique with professional guidance at the start is important for safety and progression.

Calcium and vitamin D: the nutritional foundation

Calcium: 1000-1200 mg/day in adults, preferably from whole foods (dairy, small fish eaten with the bones, leafy green vegetables, legumes, seeds, almonds). Supplements only in people with insufficient dietary intake or with established osteoporosis (with simultaneous vitamin D, avoiding very high doses).

Vitamin D: correct subclinical deficiencies with 1000-2000 IU/day; keeping 25-OH-D between 30-50 ng/mL is a reasonable goal. Essential for calcium absorption and mineralization.

Vitamin K2 (MK-7) (90-180 µg/day): activates osteocalcin; a key synergy with D3. Especially useful when high doses of D and calcium are used, to direct calcium to bone and not to vessels.

Magnesium (200-400 mg/day): cofactor in vitamin D activation and a bone component; subclinical deficiency is common.

Adequate protein (1.0-1.2 g/kg/day, up to 1.5 in older adults): the myth that "too much protein decalcifies" is incorrect; low protein intake is more problematic.

Vitamin K1 and other trace elements (boron, zinc, manganese, silicon, copper): minor cofactors with modest support, covered by a varied diet.

What damages bone

Bone densitometry (DEXA) and diagnosis

Bone mineral density is measured with DEXA. Indications: women ≥ 65 years, men ≥ 70, history of fragility fracture, family history, early menopause, significant risk factors. Results: - Normal: T-score > -1. - Osteopenia: T-score between -1 and -2.5. - Osteoporosis: T-score ≤ -2.5. - Severe osteoporosis: T-score ≤ -2.5 with a fragility fracture.

Drugs: when

In established osteoporosis or a fracture risk greater than 20% at 10 years (FRAX), oral or intravenous bisphosphonates are first-line treatment with robust data showing reduced vertebral, non-vertebral, and hip fractures (alendronate, risedronate, zoledronic acid). Alternatives: denosumab, teriparatide, romosozumab depending on context. Hormone replacement therapy in menopause also has a bone-preserving effect, although it is not mainly used for that indication.

When to see a doctor

Fragility fracture (with minimal trauma), significant height loss, persistent bone pain, and significant risk factors from age 50-60 are indications for evaluation with bone densitometry.

The reasonable conclusion

Long-term bone health is built on: regular progressive strength training from an early age as the main pillar, adequate calcium intake (preferably from food), sufficient vitamin D, K2 when appropriate, adequate protein, and avoiding tobacco and excessive alcohol. In established osteoporosis, pharmacological interventions are necessary and effective, complemented by structural measures. Fall prevention (balance training, medication review, adapting the environment) is key in older adults to prevent catastrophic fractures.

References

  1. Watson, S.L. et al. (2018). High-intensity resistance and impact training improves bone mineral density and physical function in postmenopausal women with osteopenia and osteoporosis: the LIFTMOR randomized controlled trial. J Bone Miner Res 33, 2. doi:10.1002/jbmr.3284
  2. Howe, T.E. et al. (2011). Exercise for preventing and treating osteoporosis in postmenopausal women. Cochrane Database Syst Rev 7. doi:10.1002/14651858.CD000333.pub2
  3. Knapen, M.H. et al. (2013). Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos Int 24, 9. doi:10.1007/s00198-013-2325-6
  4. Bauer, J. et al. (2013). Evidence-based recommendations for optimal dietary protein intake in older people. J Am Med Dir Assoc 14, 8. doi:10.1016/j.jamda.2013.05.021
  5. Camacho, P.M. et al. (2020). American Association of Clinical Endocrinologists/American College of Endocrinology Clinical Practice Guidelines for the Diagnosis and Treatment of Postmenopausal Osteoporosis. Endocr Pract 26, suppl 1. doi:10.4158/GL-2020-0524SUPPL