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Menopause

Menopause is the physiological transition of women to the definitive cessation of ovarian function, with a sustained drop in estrogen and progesterone; it typically occurs between ages 45 and 55 (mean age 51 in Spain); it is preceded by perimenopause (years c… Read more.

15 factors with evidence, ordered from most to least effective. Information, not medical advice.

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In depth

⏱ 3 min read

Menopause is a woman's physiological transition to the definitive cessation of ovarian function, with a sustained drop in estrogen and progesterone; it typically occurs between ages 45 and 55 (average age 51 in Spain); it is preceded by perimenopause (years with irregular cycles and initial symptoms); it can involve symptoms that vary in intensity and duration, affecting the quality of life of millions of women, and for which there are pharmacological, nutritional, and lifestyle interventions with complementary profiles.

Common symptoms

  • Hot flashes and night sweats (vasomotor symptoms): the most characteristic.
  • Insomnia and fragmented sleep.
  • Mood changes: irritability, anxiety, depression.
  • Vaginal dryness and dyspareunia.
  • Decreased libido.
  • Weight gain, redistribution of fat toward the abdomen.
  • Accelerated bone loss (first 5-10 postmenopausal years).
  • Skin changes: dryness, loss of elasticity.
  • Brain fog, difficulty concentrating.
  • Increased cardiovascular risk: loss of the protective effect of estrogen.

Hormone replacement therapy (HRT)

It is the most effective treatment for significant menopausal symptoms, with additional benefits for bone density and vaginal symptoms. After the findings of the WHI study in the early 2000s that raised concern, the modern assessment is more nuanced:

  • Early initiation (during or close to menopause, < 60 years): clearly favorable risk-benefit profile for most.
  • Late initiation (> 60 years or > 10 years post-menopause): more complex profile.
  • Transdermal route (patches, gels): better safety profile than oral for thromboembolism.
  • Combination with a progestogen in women with a uterus (micronized progesterone has a better profile than synthetic progestogens).
  • Specific contraindications: breast or endometrial cancer, active thromboembolism, active liver disease, undiagnosed vaginal bleeding.

The decision is individualized with the gynecologist, considering symptoms, personal and family history, and preferences.

Nutritional and supplement interventions with support

Soy isoflavones (40-80 mg/day): modest but significant reduction in hot flashes according to meta-analyses. Better response in women who produce equol.

Red clover isoflavones: similar support to soy.

Black cohosh: modest and heterogeneous support; traditional use in menopause.

Pueraria mirifica: a more potent phytoestrogen; caution because of its potency.

Andean maca (1,500-3,000 mg/day): improves menopausal well-being and libido without acting directly on estrogen receptors.

Sage: support for hot flashes.

Chasteberry: support for perimenopausal symptoms.

Royal jelly: modest support.

Evening primrose oil: modest support, better for breast pain than for hot flashes.

Magnesium, vitamin B6: modest support for symptoms.

Vitamin D and K2, calcium: for postmenopausal bone health.

Hydrolyzed collagen: modest support for skin and joints.

Lifestyle

  • Regular physical exercise (especially strength training): preserves muscle and bone mass, and improves mood, sleep quality, and body composition.
  • Mediterranean diet: cardiovascular effects and possibly effects on symptoms.
  • Stress management: mindfulness, yoga, meditation.
  • Good sleep hygiene.
  • Limit alcohol (worsens hot flashes and increases breast cancer risk).
  • Do not smoke.
  • Weight loss if overweight: improves vasomotor symptoms.
  • Adaptations for hot flashes: cool environment, layered clothing, avoiding spicy foods, and excess caffeine and alcohol.

Postmenopausal cardiovascular and bone health

Cardiovascular risk increases significantly after menopause. Special attention to: - Blood pressure control. - Lipid profile. - Blood glucose. - Weight and body composition. - Bone densitometry as indicated.

When to see a doctor

Climacteric symptoms with a significant impact on quality of life, postmenopausal vaginal bleeding (which should always be evaluated), evaluation of hormone therapy, and assessment of postmenopausal cardiovascular and bone risk are indications for a gynecological/medical consultation.

The reasonable conclusion

Menopause is a physiological transition that benefits from comprehensive management: hormone replacement therapy in women with significant symptoms and no contraindications (an individualized decision), nutritional and supplement interventions (phytoestrogens, maca, sage) for those who prefer or need non-hormonal options, a solid lifestyle (exercise, Mediterranean diet, sleep, no tobacco, moderate alcohol), and attention to bone health (calcium, vitamin D, K2, strength exercise, densitometry) and cardiovascular health. It is a long life stage that deserves a comprehensive medical strategy, not passive resignation.

References

  1. Taku, K. et al. (2012). Extracted or synthesized soybean isoflavones reduce menopausal hot flash frequency and severity: systematic review and meta-analysis. Menopause 19, 7. doi:10.1097/gme.0b013e3182410159
  2. Stuenkel, C.A. et al. (2015). Treatment of symptoms of the menopause: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 100, 11. doi:10.1210/jc.2015-2236
  3. Brooks, N.A. et al. (2008). Beneficial effects of Lepidium meyenii (Maca) on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen content. Menopause 15, 6. doi:10.1097/gme.0b013e3181732953
  4. Bommer, S.; Klein, P.; Suter, A. (2011). First time proof of sage's tolerability and efficacy in menopausal women with hot flushes. Adv Ther 28, 6. doi:10.1007/s12325-011-0027-z
  5. Manson, J.E. et al. (2017). Menopausal hormone therapy and long-term all-cause and cause-specific mortality: the Women's Health Initiative randomized trials. JAMA 318, 10. doi:10.1001/jama.2017.11217
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Menopause

⏱ 3 min read

Menopause is a woman's physiological transition to the definitive cessation of ovarian function, with a sustained drop in estrogen and progesterone; it typically occurs between ages 45 and 55 (average age 51 in Spain); it is preceded by perimenopause (years with irregular cycles and initial symptoms); it can involve symptoms that vary in intensity and duration, affecting the quality of life of millions of women, and for which there are pharmacological, nutritional, and lifestyle interventions with complementary profiles.

Common symptoms

Hormone replacement therapy (HRT)

It is the most effective treatment for significant menopausal symptoms, with additional benefits for bone density and vaginal symptoms. After the findings of the WHI study in the early 2000s that raised concern, the modern assessment is more nuanced:

The decision is individualized with the gynecologist, considering symptoms, personal and family history, and preferences.

Nutritional and supplement interventions with support

Soy isoflavones (40-80 mg/day): modest but significant reduction in hot flashes according to meta-analyses. Better response in women who produce equol.

Red clover isoflavones: similar support to soy.

Black cohosh: modest and heterogeneous support; traditional use in menopause.

Pueraria mirifica: a more potent phytoestrogen; caution because of its potency.

Andean maca (1,500-3,000 mg/day): improves menopausal well-being and libido without acting directly on estrogen receptors.

Sage: support for hot flashes.

Chasteberry: support for perimenopausal symptoms.

Royal jelly: modest support.

Evening primrose oil: modest support, better for breast pain than for hot flashes.

Magnesium, vitamin B6: modest support for symptoms.

Vitamin D and K2, calcium: for postmenopausal bone health.

Hydrolyzed collagen: modest support for skin and joints.

Lifestyle

Postmenopausal cardiovascular and bone health

Cardiovascular risk increases significantly after menopause. Special attention to: - Blood pressure control. - Lipid profile. - Blood glucose. - Weight and body composition. - Bone densitometry as indicated.

When to see a doctor

Climacteric symptoms with a significant impact on quality of life, postmenopausal vaginal bleeding (which should always be evaluated), evaluation of hormone therapy, and assessment of postmenopausal cardiovascular and bone risk are indications for a gynecological/medical consultation.

The reasonable conclusion

Menopause is a physiological transition that benefits from comprehensive management: hormone replacement therapy in women with significant symptoms and no contraindications (an individualized decision), nutritional and supplement interventions (phytoestrogens, maca, sage) for those who prefer or need non-hormonal options, a solid lifestyle (exercise, Mediterranean diet, sleep, no tobacco, moderate alcohol), and attention to bone health (calcium, vitamin D, K2, strength exercise, densitometry) and cardiovascular health. It is a long life stage that deserves a comprehensive medical strategy, not passive resignation.

References

  1. Taku, K. et al. (2012). Extracted or synthesized soybean isoflavones reduce menopausal hot flash frequency and severity: systematic review and meta-analysis. Menopause 19, 7. doi:10.1097/gme.0b013e3182410159
  2. Stuenkel, C.A. et al. (2015). Treatment of symptoms of the menopause: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 100, 11. doi:10.1210/jc.2015-2236
  3. Brooks, N.A. et al. (2008). Beneficial effects of Lepidium meyenii (Maca) on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen content. Menopause 15, 6. doi:10.1097/gme.0b013e3181732953
  4. Bommer, S.; Klein, P.; Suter, A. (2011). First time proof of sage's tolerability and efficacy in menopausal women with hot flushes. Adv Ther 28, 6. doi:10.1007/s12325-011-0027-z
  5. Manson, J.E. et al. (2017). Menopausal hormone therapy and long-term all-cause and cause-specific mortality: the Women's Health Initiative randomized trials. JAMA 318, 10. doi:10.1001/jama.2017.11217