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Mechanism

Hormonal system

Connects with 58 factors and 2 health goals.

In depth

Hormonal system

⏱ 2 min read

The hormonal (or endocrine) system is the network of glands that makes hormones —chemical messengers that travel through the blood— to coordinate functions throughout the body: metabolism, growth, reproduction, stress, sleep, and mood. It acts more slowly than the nervous system but with broad and sustained effects.

On this map it is a central pathway that connects with sex hormones, insulin and glucose, cortisol, thyroid hormones, melatonin, and the HPA axis, and with many metabolic and wellness goals. Sleep, diet, exercise, and stress management are the levers that most influence hormonal balance.

Educational information, not medical advice.

Factors that act through this pathway

Supplements

AshwagandhaBerberineBoronFenugreekGlycineInositolL-theanineMagnesiumRhodiolaShilajitTaurineVitamin DSeleniumTongkat AliPhosphatidylserineEpitalonMOTS-cTUDCALactobacillus rhamnosus JB-1 (psychobiotic)Bifidobacterium longum 1714 (psychobiotic)D-aspartic acid (DAA)

Diet

Fasting-mimicking diet (FMD)Protein intake (by age)Cruciferous (brassica) vegetables in excess

Nutrients

Pantothenic acid (Vitamin B5)

Prescription drugs

Acarbose (and others)Retatrutide (triple agonist)TesamorelinCJC-1295

Lifestyle

Contact with natureSleep deprivation (moderate restriction)Multimodal anti-decline program (Bredesen/ReCODE)Caloric restrictionType of exercise (HIIT vs strength vs combined)Cold exposure4-7-8 breathingAlternate nostril breathing (Nadi Shodhana)

Related pathways and factors

Serotonin (5-HT)OxytocinEndorphins and the endogenous opioid systemAnandamide and endocannabinoidsNeuropeptide Y (NPY)CortisolEstrogensProgesteroneThyroid hormones (T3, T4)InsulinLeptin and GhrelinNAD+FOXOSirtuins (SIRT1–SIRT7)Beta-hydroxybutyrate (BHB)Toll-like receptors (TLR)

Related goals

Chronic stress and HPASocial anxiety

Information, not medical advice.

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