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Mechanism

Acid-base balance and kidney function

Connects with 60 factors and 2 health goals.

In depth

Acid-base balance and kidney function

⏱ 2 min read

Acid-base balance is the maintenance of blood pH within a very narrow range, essential for enzymes and cells to function. The kidney and the lungs are the main regulators: the kidney adjusts acid excretion and bicarbonate reabsorption, in addition to filtering the blood and controlling water, electrolytes, and blood pressure.

On this map it connects with blood pressure, detoxification, and goals where kidney health and mineral management matter. Adequate hydration, electrolyte balance, and not overloading the kidney with excess protein or toxins help preserve this function.

Educational information, not medical advice.

Factors that act through this pathway

Supplements

AshwagandhaCalciumExogenous ketone estersWhole coffee fruit extractL-theanineMagnesiumMangiferin + luteolin (Zynamite)Quercetin and EGCG (green tea) as zinc ionophoresRhodiolaTaurineGreen teaL-carnitineTongkat AliPhosphatidylserinePeptidesAstragalusSodium bicarbonateBranched-chain amino acids (BCAA)Lactobacillus reuteri

Diet

Weight-loss dietsProlonged fastingOxalates (oxalate-rich foods)Fish in pregnancyAlkaline diet (fruits and vegetables)

Nutrients

Pentadecanoic acid (C15:0)Protein (amount for muscle)

Prescription drugs

Anti-PCSK9 antibodiesPotassium citrate

Lifestyle

Intensive lifestyle changes (Ornish program)Sleep determinants (sleep hygiene)Exercise (on lipids)Aerobic exerciseExercise + intermittent fasting (combined)Exercise (type) for boneLifestyle (and Parkinson's)Lifestyle vs metformin (prevention)Exercise timing (afternoon vs morning)Multimodal anti-decline program (Bredesen/ReCODE)Protein (distribution throughout the day)Deep sleep (slow waves)Heat therapy (sauna / hot baths)Contrast therapy (cold/hot water)Red light therapy (photobiomodulation)Cold exposure4-7-8 breathing

Related pathways and factors

BDNFNorepinephrine (noradrenaline)OxytocinEndorphins and the endogenous opioid systemAnandamide and endocannabinoidsTestosteroneEstrogensLeptin and GhrelinAutophagySirtuins (SIRT1–SIRT7)Cellular senescenceButyrateThymic involution

Others

Zonulin (marker of 'leaky gut')

Related goals

KidneyMetabolic acidosis

Information, not medical advice.

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